Explained: Crib, found in the world’s rare blood group Bengaluru woman
Medical History Revint: Bangalore Woman, Ultra-rair Cribly Blood Group was discovered among Stun scientists
In short
- Bengaluru woman is the first known person in the world with newly identified cradle blood group
- Crib Crommer is part of the blood group system, but already carries out the antigen
- Panoracitance appeared in her blood, in which all the available donors including family were rejected.
In a groundbreaking progress in the world of Transfusion Medicine, researchers have identified an unknown and ultra-rair human blood group, a pre-unknown and ultra-rair. The discovery by a team of scientists in India and the UK can be the major implications for the global care, prenatal diagnosis and blood donation protocols.
What is cradle blood group?
Cribly blood group is a newly identified blood type outside the existing major systems such as ABO and RH. Krib means “the chromosome region is identified as a blood group”, although it is briefly symbolically newborn and its relevance in fetal medicine. It belongs to the INRA (Indian rare antigen) blood group system, which was officially recognized by the International Society of Blood Transfusion (ISBT) in 2022.
The cradle is characterized by the absence of a high-east antigen found in most people. Individuals with cradle blood group lack this normal antigen, causing blood transfusion to be extremely complex, only other crib-negative blood can be used, which is extremely rare.
Why is cradle blood group important?
While only a handful of people worldwide are known for blood type, its discovery is medically important. It plays an important role in cases of hemolytic disease of the fetus and newborn (HDFN), where the mother has attacked the red blood cells of the fetus. In such cases the cradle can help prevent fatal complications during pregnancy at the beginning of the group.
Science behind search
The blood group was first identified in a Gujarat patient, which required a transaction, but no compatible blood could be found in regular or rare donor registries. Further investigation revealed the presence of a novel antigen profile. Genetic analysis confirmed that it was a completely new antigen that did not fit in 43 known blood group systems previously recognized by ISBT.
After further verification and colleague reviews, the Crib Blood Group was formally classified and added to the expansion database of human blood group systems.
Implications for India and the world
India, with its genetically diverse population, is already a site of many rare blood discoveries. The Inra Blood Group was first recognized in an Indian woman in 2017. With CRIB now joining the list, Indian medical authorities are undergoing pressure on Indian medical authorities investing in rare blood banks, expanding donor registries and increasing pressure for pregnant women in genetic screening programs.
Globally, the discovery adds another layer to understand human immunohematology. For physicians, it means adjusting existing transfers strategies. For researchers, it presents a new area of study related to genetics, population migration and disease management.
What will happen next?
Researchers are calling for the development of a crib-specific antibody panels and screening tests that can help identify the carrier quickly. Efforts are also underway to raise awareness among health professionals, especially in areas with high ethnic diversity.
The discovery of the cradle blood group reminds us how unknown our own biology is still and how those mystery can be directly affected.
Quick facts: cradle blood group
- Full form: chromosome region is identified as a blood group
- Category: part of INRA (Indian rare antigen) system
- Facked in India confirmed by international experts
- Importance: Embryo-metal blood compatibility and important in rare infections
- Community: less than 10 known cases worldwide
